Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle

Friedreich’s ataxia (FRDA) is an inherited disorder caused by reduced levels of frataxin (FXN), which is required for iron-sulfur cluster biogenesis. Neurological and cardiac comorbidities are prominent and have been a major focus of study. Skeletal muscle has received less attention despite indicat...

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Detalles Bibliográficos
Autores principales: Vásquez-Trincado, César, Dunn, Julia, Han, Ji In, Hymms, Briyanna, Tamaroff, Jaclyn, Patel, Monika, Nguyen, Sara, Dedio, Anna, Wade, Kristin, Enigwe, Chinazo, Nichtova, Zuzana, Lynch, David R., Csordas, Gyorgy, McCormack, Shana E., Seifert, Erin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090249/
https://www.ncbi.nlm.nih.gov/pubmed/35531957
http://dx.doi.org/10.1172/jci.insight.155201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090249/
https://www.ncbi.nlm.nih.gov/pubmed/35531957
http://dx.doi.org/10.1172/jci.insight.155201

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