Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8(+) T cell antitumor immunity

To elicit effective antitumor responses, CD8(+) T cells need to infiltrate tumors and sustain their effector function within the immunosuppressive tumor microenvironment (TME). Here, we evaluate the role of MNK activity in regulating CD8(+) T cell infiltration and antitumor activity in pancreatic an...

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Detalles Bibliográficos
Autores principales: Pham, Thao N.D., Spaulding, Christina, Shields, Mario A., Metropulos, Anastasia E., Shah, Dhavan N., Khalafalla, Mahmoud G., Principe, Daniel R., Bentrem, David J., Munshi, Hidayatullah G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090262/
https://www.ncbi.nlm.nih.gov/pubmed/35380995
http://dx.doi.org/10.1172/jci.insight.152731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090262/
https://www.ncbi.nlm.nih.gov/pubmed/35380995
http://dx.doi.org/10.1172/jci.insight.152731

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