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Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle

The redox reagent dithiothreitol (DTT) causes stress in the endoplasmic reticulum (ER) by disrupting its oxidative protein folding environment, which results in the accumulation and misfolding of the newly synthesized proteins. DTT may potentially impact cellular physiology by ER-independent mechani...

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Detalles Bibliográficos
Autores principales: G, Gokul, Singh, Jogender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090326/
https://www.ncbi.nlm.nih.gov/pubmed/35438636
http://dx.doi.org/10.7554/eLife.76021