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Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle
The redox reagent dithiothreitol (DTT) causes stress in the endoplasmic reticulum (ER) by disrupting its oxidative protein folding environment, which results in the accumulation and misfolding of the newly synthesized proteins. DTT may potentially impact cellular physiology by ER-independent mechani...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090326/ https://www.ncbi.nlm.nih.gov/pubmed/35438636 http://dx.doi.org/10.7554/eLife.76021 |