Cargando…

GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains limited by systemic toxicity and chemotherapy resistance. Therefore, nanoparticle-mediated delivery of cytotoxic agents selectively to cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090371/ https://www.ncbi.nlm.nih.gov/pubmed/35532120 http://dx.doi.org/10.1080/10717544.2022.2069302

Ejemplares similares

CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma
por: Rioja-Blanco, Elisa, et al.
Publicado: (2022)

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo
por: Núñez, Yáiza, et al.
Publicado: (2023)

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors
por: Rioja-Blanco, Elisa, et al.
Publicado: (2022)

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model
por: Rioja-Blanco, Elisa, et al.
Publicado: (2022)

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease
por: Medina-Gutiérrez, Esperanza, et al.
Publicado: (2022)

Selective delivery of T22-PE24-H6 to CXCR4(+) diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model
por: Falgàs, Aïda, et al.
Publicado: (2020)

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination
por: Pallarès, Victor, et al.
Publicado: (2020)

Intracellular CXCR4(+) cell targeting with T22-empowered protein-only nanoparticles
por: Unzueta, Ugutz, et al.
Publicado: (2012)

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models
por: Medina-Gutiérrez, Esperanza, et al.
Publicado: (2022)

Efficient bioactive oligonucleotide‐protein conjugation for cell‐targeted cancer therapy
por: Aviñó, Anna, et al.
Publicado: (2019)

Selective depletion of metastatic stem cells as therapy for human colorectal cancer
por: Céspedes, María Virtudes, et al.
Publicado: (2018)

Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells
por: Falgàs, Aïda, et al.
Publicado: (2021)

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4(+) Cancers
por: Cano-Garrido, Olivia, et al.
Publicado: (2021)

A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models
por: Falgàs, Aïda, et al.
Publicado: (2020)

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles
por: Álamo, Patricia, et al.
Publicado: (2020)

Artificial Inclusion Bodies for Clinical Development
por: Sánchez, Julieta M., et al.
Publicado: (2019)

Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4
por: Serna, Naroa, et al.
Publicado: (2021)

Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials
por: Serna, Naroa, et al.
Publicado: (2022)

Self-Assembled Nanobodies as Selectively Targeted, Nanostructured, and Multivalent Materials
por: Sánchez-García, Laura, et al.
Publicado: (2021)

Ion-dependent slow protein release from in vivo disintegrating micro-granules
por: Álamo, Patricia, et al.
Publicado: (2021)

Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models
por: Alamo, Patricia, et al.
Publicado: (2014)

The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles
por: Voltà-Durán, Eric, et al.
Publicado: (2022)

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
por: Sborgi, Lorenzo, et al.
Publicado: (2016)

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs
por: Céspedes, María Virtudes, et al.
Publicado: (2016)

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli
por: Rueda, Fabián, et al.
Publicado: (2016)

CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis
por: Moreno, María José, et al.
Publicado: (2018)

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
por: Pavón, Miguel Angel, et al.
Publicado: (2016)

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients
por: Pavón, Miguel Angel, et al.
Publicado: (2015)

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice
por: Kang, Lulu, et al.
Publicado: (2022)

Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo
por: Chen, Yue, et al.
Publicado: (2023)

An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials
por: Parladé, Eloi, et al.
Publicado: (2022)

High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma
por: Téllez-Gabriel, Marta, et al.
Publicado: (2013)

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
por: Yang, Ye, et al.
Publicado: (2020)

Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis
por: Li, Nan, et al.
Publicado: (2021)

The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies
por: Sánchez, Julieta María, et al.
Publicado: (2022)

Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway
por: Ding, Peng, et al.
Publicado: (2023)

Pyroptotic and non‐pyroptotic effector functions of caspase‐11
por: Abu Khweek, Arwa, et al.
Publicado: (2020)

Toxicity Profiling of Bacterial Inclusion Bodies in Human Caco-2 Cells
por: Barguilla, Irene, et al.
Publicado: (2022)

Statins as anti-pyroptotic agents
por: Khalifeh, Masoomeh, et al.
Publicado: (2021)

Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation
por: Serna, Naroa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rffejdq49ak7264nkb1ukqkbda