β-Hydroxybutyrate Exacerbates Hypoxic Injury by Inhibiting HIF-1α-Dependent Glycolysis in Cardiomyocytes—Adding Fuel to the Fire?

PURPOSE: Ketone body oxidation yields more ATP per mole of consumed oxygen than glucose. However, whether an increased ketone body supply in hypoxic cardiomyocytes and ischemic hearts is protective or not remains elusive. The goal of this study is to determine the effect of β-hydroxybutyrate (β-OHB)...

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Detalles Bibliográficos
Autores principales: Ma, Xiurui, Dong, Zhen, Liu, Jingyi, Ma, Leilei, Sun, Xiaolei, Gao, Rifeng, Pan, Lihong, Zhang, Jinyan, A, Dilan, An, Jian, Hu, Kai, Sun, Aijun, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090701/
https://www.ncbi.nlm.nih.gov/pubmed/34652582
http://dx.doi.org/10.1007/s10557-021-07267-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090701/
https://www.ncbi.nlm.nih.gov/pubmed/34652582
http://dx.doi.org/10.1007/s10557-021-07267-y

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