An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters

Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool to reduce mitochondrial iron and ROS levels, we arrived at a molecule that destabilizes the...

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Detalles Bibliográficos
Autores principales: Marjault, Henri-Baptiste, Karmi, Ola, Zuo, Ke, Michaeli, Dorit, Eisenberg-Domovich, Yael, Rossetti, Giulia, de Chassey, Benoit, Vonderscher, Jacky, Cabantchik, Ioav, Carloni, Paolo, Mittler, Ron, Livnah, Oded, Meldrum, Eric, Nechushtai, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090738/
https://www.ncbi.nlm.nih.gov/pubmed/35538231
http://dx.doi.org/10.1038/s42003-022-03393-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090738/
https://www.ncbi.nlm.nih.gov/pubmed/35538231
http://dx.doi.org/10.1038/s42003-022-03393-x

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