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Coevolution of interacting proteins through non-contacting and non-specific mutations
Proteins often accumulate neutral mutations that do not affect current functions but can profoundly influence future mutational possibilities and functions. Understanding such hidden potential has major implications for protein design and evolutionary forecasting, but has been limited by a lack of s...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090974/ https://www.ncbi.nlm.nih.gov/pubmed/35361892 http://dx.doi.org/10.1038/s41559-022-01688-0 |