Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice

Non-sensory cells in the sensory epithelium of the cochlea are connected extensively by gap junctions. Functionally null mutations in GJB6 (encoding Cx30) cause hearing loss in humans. In this study, we injected AAV1-CB7-Gjb2 into the scala media between P0-2 in the cochlea of Gjb6 (−/−) mice. The i...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Wang, Wenwen, Kim, Sun Myoung, Wang, Jianjun, Zhou, Binfei, Kong, Weijia, Zheng, James, Lin, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091169/
https://www.ncbi.nlm.nih.gov/pubmed/35573684
http://dx.doi.org/10.3389/fcell.2022.900416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091169/
https://www.ncbi.nlm.nih.gov/pubmed/35573684
http://dx.doi.org/10.3389/fcell.2022.900416

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