The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...

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Detalles Bibliográficos
Autores principales: Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091257/
https://www.ncbi.nlm.nih.gov/pubmed/35538063
http://dx.doi.org/10.1038/s41467-022-29609-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091257/
https://www.ncbi.nlm.nih.gov/pubmed/35538063
http://dx.doi.org/10.1038/s41467-022-29609-6

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