Cargando…
The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091257/ https://www.ncbi.nlm.nih.gov/pubmed/35538063 http://dx.doi.org/10.1038/s41467-022-29609-6 |