Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue

Each heartbeat is initiated by specialized pacemaker cells operating within the sinoatrial node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of their electrophysiological parameters and Ca cycling, the role of this heterogeneity for cardiac pacemaker function rem...

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Detalles Bibliográficos
Autores principales: Maltsev, Alexander V., Stern, Michael D., Lakatta, Edward G., Maltsev, Victor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091312/
https://www.ncbi.nlm.nih.gov/pubmed/35574456
http://dx.doi.org/10.3389/fphys.2022.845634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091312/
https://www.ncbi.nlm.nih.gov/pubmed/35574456
http://dx.doi.org/10.3389/fphys.2022.845634

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