Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice

Although the antitumor efficacy of immune checkpoint blockade (ICB) has been proved in colorectal cancer (CRC), the results are unsatisfactory, presumably owing to the presence of tryptophan metabolism enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2). However, onl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Rongjie, Wang, Yuanfeiyi, Liu, Dan, Luo, Qing, Du, Peixin, Zhang, Haiyan, Wu, Wenshuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091350/
https://www.ncbi.nlm.nih.gov/pubmed/35571116
http://dx.doi.org/10.3389/fphar.2022.870848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091350/
https://www.ncbi.nlm.nih.gov/pubmed/35571116
http://dx.doi.org/10.3389/fphar.2022.870848

Ejemplares similares