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Cholesterol-sensing role of phenylalanine in the interaction of human islet amyloid polypeptide with lipid bilayers
The interactions between hIAPP and the pancreatic β-cells are associated with β-cell death in type II diabetes. Cholesterol modulates hIAPP-membrane interaction and hIAPP aggregation. The molecular mechanism underlying this is not well understood. Here we explore the cholesterol-sensing role of F15...
Autores principales: | Hao, Ruijie, Li, Yang, Guan, Liping, Lu, Tong, Meng, Feihong, Wang, Chunyu, Li, Fei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091444/ https://www.ncbi.nlm.nih.gov/pubmed/35557876 http://dx.doi.org/10.1039/c8ra07310d |
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