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(19)F multiple-quantum coherence NMR spectroscopy for probing protein–ligand interactions
A new (19)F NMR method is presented which can be used to detect weak protein binding of small molecules with up to mM affinity. The method capitalizes on the synthetic availability of unique SF(5) containing compounds and the generation of five-quantum coherences (5QC). Given the high sensitivity of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091488/ https://www.ncbi.nlm.nih.gov/pubmed/35557931 http://dx.doi.org/10.1039/c8ra09296f |