Cargando…
Targeting HCV polymerase: a structural and dynamic perspective into the mechanism of selective covalent inhibition
Background: Concerns have been raised over the emerging pandemic status of hepatitis C virus (HCV). Current available drugs lack specificity, stability and potency. The HCV NS5B RNA-dependent RNA polymerase (RdRp) is a vital component in viral replication and is often targeted in antiviral therapies...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092151/ https://www.ncbi.nlm.nih.gov/pubmed/35558797 http://dx.doi.org/10.1039/c8ra07346e |