A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD

Type 2N von Willebrand disease is caused by mutations in the factor VIII (FVIII) binding site of von Willebrand factor (VWF), resulting in dysfunctional VWF with defective binding capacity for FVIII. We developed a novel type 2N mouse model using CRISPR/Cas9 technology. In homozygous VWF(2N/2N) mice...

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Detalles Bibliográficos
Autores principales: Shi, Qizhen, Fahs, Scot A., Mattson, Jeremy G., Yu, Hongyin, Perry, Crystal L., Morateck, Patricia A., Schroeder, Jocelyn A., Rapten, Jessica, Weiler, Hartmut, Montgomery, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092403/
https://www.ncbi.nlm.nih.gov/pubmed/35015821
http://dx.doi.org/10.1182/bloodadvances.2021006353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092403/
https://www.ncbi.nlm.nih.gov/pubmed/35015821
http://dx.doi.org/10.1182/bloodadvances.2021006353

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