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Structural impact of thioamide incorporation into a β-hairpin

The thioamide is a naturally-occurring single atom substitution of the canonical amide bond. The exchange of oxygen to sulfur alters the amide's physical and chemical characteristics, thereby expanding its functionality. Incorporation of thioamides in prevalent secondary structures has demonstr...

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Detalles Bibliográficos
Autores principales: Fiore, Kristen E., Patist, Martijn J., Giannakoulias, Sam, Huang, Cheng-Hsin, Verma, Hitesh, Khatri, Bhavesh, Cheng, Richard P., Chatterjee, Jayanta, Petersson, E. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092430/
https://www.ncbi.nlm.nih.gov/pubmed/35656485
http://dx.doi.org/10.1039/d1cb00229e