Cargando…
Understanding p300-transcription factor interactions using sequence variation and hybridization
The hypoxic response is central to cell function and plays a significant role in the growth and survival of solid tumours. HIF-1 regulates the hypoxic response by activating over 100 genes responsible for adaptation to hypoxia, making it a potential target for anticancer drug discovery. Although the...
Autores principales: | Hóbor, Fruzsina, Hegedüs, Zsófia, Ibarra, Amaurys Avila, Petrovicz, Vencel L., Bartlett, Gail J., Sessions, Richard B., Wilson, Andrew J., Edwards, Thomas A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092470/ https://www.ncbi.nlm.nih.gov/pubmed/35656479 http://dx.doi.org/10.1039/d2cb00026a |
Ejemplares similares
-
Predicting and Experimentally Validating Hot-Spot
Residues at Protein–Protein Interfaces
por: Ibarra, Amaurys A., et al.
Publicado: (2019) -
Query-guided protein–protein interaction inhibitor discovery
por: Celis, Sergio, et al.
Publicado: (2021) -
Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)
por: Hetherington, Kristina, et al.
Publicado: (2021) -
Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates
por: Kupihár, Zoltán, et al.
Publicado: (2023) -
Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation
por: Hegedüs, Zsófia, et al.
Publicado: (2021)