Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation

RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras mutations in blood cells leads to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-Ras(G12D) activates Stat5 to dysregulate stem cell function. However, the underlying m...

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Detalles Bibliográficos
Autores principales: Jin, Xi, Ng, Victor, Zhao, Meiling, Liu, Lu, Higashimoto, Tomoyasu, Lee, Zheng Hong, Chung, Jooho, Chen, Victor, Ney, Gina, Kandarpa, Malathi, Talpaz, Moshe, Li, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092650/
https://www.ncbi.nlm.nih.gov/pubmed/35352806
http://dx.doi.org/10.1242/dmm.049088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092650/
https://www.ncbi.nlm.nih.gov/pubmed/35352806
http://dx.doi.org/10.1242/dmm.049088

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