Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa

The P23H mutation in rhodopsin (Rho), the rod visual pigment, is the most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). The fate of misfolded mutant Rho in rod photoreceptors has yet to be elucidated. We generated a new mouse model, in which the P23H-Rho mutant allele...

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Detalles Bibliográficos
Autores principales: Robichaux, Michael A., Nguyen, Vy, Chan, Fung, Kailasam, Lavanya, He, Feng, Wilson, John H., Wensel, Theodore G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092655/
https://www.ncbi.nlm.nih.gov/pubmed/35275162
http://dx.doi.org/10.1242/dmm.049336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092655/
https://www.ncbi.nlm.nih.gov/pubmed/35275162
http://dx.doi.org/10.1242/dmm.049336

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