Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products

N(6)-Methyladenosine (m(6)A) is the most prevalent mRNA modification in mammalian cells that is mainly catalyzed by the methyltransferase complex of methyltransferase-like 3 and methyltransferase-like 14 (METTL3-METTL14). Many lines of evidence suggest that METTL3 plays important roles in several di...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Yue, Yuan, Yongliang, Xu, Le, Zhao, Fang, Wang, Wenbin, Xu, Yiping, Tian, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093036/
https://www.ncbi.nlm.nih.gov/pubmed/35571106
http://dx.doi.org/10.3389/fphar.2022.878135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093036/
https://www.ncbi.nlm.nih.gov/pubmed/35571106
http://dx.doi.org/10.3389/fphar.2022.878135

Ejemplares similares