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Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products

N(6)-Methyladenosine (m(6)A) is the most prevalent mRNA modification in mammalian cells that is mainly catalyzed by the methyltransferase complex of methyltransferase-like 3 and methyltransferase-like 14 (METTL3-METTL14). Many lines of evidence suggest that METTL3 plays important roles in several di...

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Detalles Bibliográficos
Autores principales:	Du, Yue, Yuan, Yongliang, Xu, Le, Zhao, Fang, Wang, Wenbin, Xu, Yiping, Tian, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093036/ https://www.ncbi.nlm.nih.gov/pubmed/35571106 http://dx.doi.org/10.3389/fphar.2022.878135

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