Triazolinedione protein modification: from an overlooked off-target effect to a tryptophan-based bioconjugation strategy

Labelling of tyrosine residues in peptides and proteins has been reported to selectively occur via a ‘tyrosine-click’ reaction with triazolinedione reagents (TAD). However, we here demonstrate that TAD reagents are actually not selective for tyrosine and that tryptophan residues are in fact also lab...

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Detalles Bibliográficos
Autores principales: Decoene, Klaas W., Unal, Kamil, Staes, An, Zwaenepoel, Olivier, Gettemans, Jan, Gevaert, Kris, Winne, Johan M., Madder, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093138/
https://www.ncbi.nlm.nih.gov/pubmed/35655564
http://dx.doi.org/10.1039/d1sc06942j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093138/
https://www.ncbi.nlm.nih.gov/pubmed/35655564
http://dx.doi.org/10.1039/d1sc06942j

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