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Triazolinedione protein modification: from an overlooked off-target effect to a tryptophan-based bioconjugation strategy
Labelling of tyrosine residues in peptides and proteins has been reported to selectively occur via a ‘tyrosine-click’ reaction with triazolinedione reagents (TAD). However, we here demonstrate that TAD reagents are actually not selective for tyrosine and that tryptophan residues are in fact also lab...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093138/ https://www.ncbi.nlm.nih.gov/pubmed/35655564 http://dx.doi.org/10.1039/d1sc06942j |