Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu(+) supplants entropically favoured Zn(2+) to form Cu(4)(+) clusters under physiological conditions

Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in metal homeostasis and detoxification. While known for their high affinity for d(10) metal ions, there is a surprising dearth of thermodynamic data on metals binding to MTs. In this study, Zn(2+) and Cu(+) bindi...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehlenbacher, Matthew R., Elsiesy, Rahma, Lakha, Rabina, Villones, Rhiza Lyne E., Orman, Marina, Vizcarra, Christina L., Meloni, Gabriele, Wilcox, Dean E., Austin, Rachel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093145/
https://www.ncbi.nlm.nih.gov/pubmed/35655557
http://dx.doi.org/10.1039/d2sc00676f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093145/
https://www.ncbi.nlm.nih.gov/pubmed/35655557
http://dx.doi.org/10.1039/d2sc00676f

Ejemplares similares