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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu(+) supplants entropically favoured Zn(2+) to form Cu(4)(+) clusters under physiological conditions
Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in metal homeostasis and detoxification. While known for their high affinity for d(10) metal ions, there is a surprising dearth of thermodynamic data on metals binding to MTs. In this study, Zn(2+) and Cu(+) bindi...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093145/ https://www.ncbi.nlm.nih.gov/pubmed/35655557 http://dx.doi.org/10.1039/d2sc00676f |