Cargando…

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine

BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: Pruritogenicity of lysophosphatidylcholi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yong, Wang, Zi-Long, Yeo, Michele, Zhang, Qiao-Juan, López-Romero, Ana E., Ding, Hui-Ping, Zhang, Xin, Zeng, Qian, Morales-Lázaro, Sara L., Moore, Carlene, Jin, Ying-Ai, Yang, Huang-He, Morstein, Johannes, Bortsov, Andrey, Krawczyk, Marcin, Lammert, Frank, Abdelmalek, Manal, Diehl, Anna Mae, Milkiewicz, Piotr, Kremer, Andreas E., Zhang, Jennifer Y., Nackley, Andrea, Reeves, Tony E., Ko, Mei-Chuan, Ji, Ru-Rong, Rosenbaum, Tamara, Liedtke, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093619/ https://www.ncbi.nlm.nih.gov/pubmed/33819485 http://dx.doi.org/10.1053/j.gastro.2021.03.049

Ejemplares similares

Variant adiponutrin confers genetic protection against cholestatic itch
por: Krawczyk, Marcin, et al.
Publicado: (2014)

Serum Autotaxin is a Marker of the Severity of Liver Injury and Overall Survival in Patients with Cholestatic Liver Diseases
por: Wunsch, Ewa, et al.
Publicado: (2016)

Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage‐refractory itch
por: Holz, Robert, et al.
Publicado: (2018)

PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC
por: Kruk, Beata, et al.
Publicado: (2018)

MRGPRX4 is a bile acid receptor for human cholestatic itch
por: Yu, Huasheng, et al.
Publicado: (2019)

Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial
por: Bolier, Ruth, et al.
Publicado: (2017)

Identification of a bilirubin receptor that may mediate a component of cholestatic itch
por: Meixiong, James, et al.
Publicado: (2019)

Non-dermatological Challenges of Chronic Itch
por: KREMER, Andreas E., et al.
Publicado: (2020)

Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats
por: Tian, Bin, et al.
Publicado: (2016)

Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis
por: Haijer, Floris W., et al.
Publicado: (2023)

Itch in Psoriasis
por: Grattan, Clive E. H.
Publicado: (1985)

Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery
por: Huang, Meiling, et al.
Publicado: (2022)

Current Therapies for Cholestatic Diseases
por: Méndez-Sánchez, Nahum, et al.
Publicado: (2023)

The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3
por: Zhang, Qing, et al.
Publicado: (2021)

Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver
por: Lehmann, Rainer, et al.
Publicado: (2013)

Itch itch with not a wink of sleep
por: Baruah, Rishiraj, et al.
Publicado: (2014)

Itch Beyond the Skin—Mucosal Itch
por: Lesslar, Olivia J. Ly, et al.
Publicado: (2021)

The Role of Inflammation in Cholestatic Liver Injury
por: Chen, Jie, et al.
Publicado: (2023)

An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases
por: Law, Shi-Hui, et al.
Publicado: (2019)

Targeting lipid droplet lysophosphatidylcholine for cisplatin chemotherapy
por: Chen, Lumin, et al.
Publicado: (2020)

Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa
por: Sueajai, Jetjamnong, et al.
Publicado: (2022)

Lysophosphatidylcholine: Potential Target for the Treatment of Chronic Pain
por: Ren, Jinxuan, et al.
Publicado: (2022)

Fine‐Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease
por: Blokker, Britt A., et al.
Publicado: (2019)

Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
por: Morales-Lázaro, Sara L., et al.
Publicado: (2016)

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions
por: Perreault, Martin, et al.
Publicado: (2018)

On Itch
Publicado: (1865)

Itching
Publicado: (1899)

The Itch
Publicado: (1871)

Itch
Publicado: (1872)

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study
por: Wegermann, Kara, et al.
Publicado: (2018)

Itching eyes after itching around the head
por: Tabuenca Del Barrio, Laura, et al.
Publicado: (2020)

Whole‐Exome Sequencing Study of Extreme Phenotypes of NAFLD
por: Kleinstein, Sarah E., et al.
Publicado: (2018)

Severe Cholestatic Hepatitis Secondary to SARS-CoV-2
por: Lindholm, Christopher R., et al.
Publicado: (2022)

Effects of Lysophosphatidylcholine on Intestinal Health of Turbot Fed High-Lipid Diets
por: Li, Sihui, et al.
Publicado: (2022)

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
por: Farquhar, Marilyn G., et al.
Publicado: (1963)

Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey‐Based Study
por: Glass, Oliver, et al.
Publicado: (2021)

Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
por: Silva-Neto, Mário A. C., et al.
Publicado: (2012)

Lysophosphatidylcholine inhibits membrane-associated SNARE complex disassembly
por: Shin, Leah, et al.
Publicado: (2012)

Alterations of Plasma Lysophosphatidylcholine Species in Obesity and Weight Loss
por: Heimerl, Susanne, et al.
Publicado: (2014)

Effects of Lysophosphatidylcholine on Jejuna Morphology and Its Potential Mechanism
por: Li, Xiaofeng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7id3r4qfssvvtk8ugpvhklho88