Cargando…

An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection

Local antibiotic therapy is increasingly being recognised for its role in preventing and treating orthopaedic device-related infection (ODRI). A bioresorbable, injectable gentamicin-loaded hydrogel has been developed to deliver local antibiotics at the time of surgery with potential for both prevent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boot, Willemijn, Foster, Andrew Lewis, Guillaume, Olivier, Eglin, David, Schmid, Tanja, D’Este, Matteo, Zeiter, Stephan, Richards, Robert Geoff, Moriarty, Thomas Fintan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093643/ https://www.ncbi.nlm.nih.gov/pubmed/35573772 http://dx.doi.org/10.3389/fcimb.2022.826392

Ejemplares similares

Antibiofilm efficacy of focused high-energy extracorporeal shockwaves and antibiotics in vitro
por: Milstrey, Alexander, et al.
Publicado: (2021)

An Enzybiotic Regimen for the Treatment of Methicillin-Resistant Staphylococcus aureus Orthopaedic Device-Related Infection
por: Sumrall, Eric T., et al.
Publicado: (2021)

Intraoperative loading of calcium phosphate-coated implants with gentamicin prevents experimental Staphylococcus aureus infection in vivo
por: Thompson, Keith, et al.
Publicado: (2019)

Calcium phosphate/thermoresponsive hyaluronan hydrogel composite delivering hydrophilic and hydrophobic drugs
por: Petta, Dalila, et al.
Publicado: (2015)

Local Bacteriophage Delivery for Treatment and Prevention of Bacterial Infections
por: Rotman, Stijn Gerard, et al.
Publicado: (2020)

Challenges to establish the diagnosis of aspergillosis in non-laboratory animals: looking for alternatives in veterinary medicine and demonstration of feasibility through two concrete examples in penguins and dolphins
por: Desoubeaux, Guillaume, et al.
Publicado: (2022)

Epidemiology of Pneumocystis jirovecii Pneumonia and (Non-)use of Prophylaxis
por: Dunbar, Albert, et al.
Publicado: (2020)

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi
por: Ren, Youliang, et al.
Publicado: (2022)

Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell migration and alignment
por: Schwab, A., et al.
Publicado: (2020)

Antibiotic prophylaxis is not indicated prior to dental procedures for prevention of periprosthetic joint infections: A systematic review and new guidelines from the Dutch Orthopaedic and Dental Societies
por: Rademacher, Willem M H, et al.
Publicado: (2017)

Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus: a Preclinical Study
por: Onsea, Jolien, et al.
Publicado: (2021)

The effect of local antibiotic prophylaxis when treating open limb fractures: A systematic review and meta-analysis
por: Morgenstern, M., et al.
Publicado: (2018)

Shotgun sequencing of sonication fluid for the diagnosis of orthopaedic implant-associated infections with Cutibacterium acnes as suspected causative agent
por: Ponraj, Diana Salomi, et al.
Publicado: (2023)

Demonstration and Characterization of Cyst-Like Structures in the Life Cycle of Trichomonas vaginalis
por: Beri, Divya, et al.
Publicado: (2020)

Comparative bone healing with induced membrane technique (IMT) versus empty defects in septic and aseptic conditions in a novel rabbit humerus model
por: Siverino, Claudia, et al.
Publicado: (2023)

Rapid hydrogel-based phage susceptibility test for pathogenic bacteria
por: Patpatia, Sheetal, et al.
Publicado: (2022)

Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells
por: Hargrave, Kerrie E., et al.
Publicado: (2019)

Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis
por: Mohammadi, Nasibeh, et al.
Publicado: (2021)

Firmicutes Dysbiosis After Chlorhexidine Prophylaxis in Healthy Patients Submitted to Impacted Lower Third Molar Extraction
por: Neves, Carlos Augusto das, et al.
Publicado: (2021)

Segmental induction heating of orthopaedic metal implants
por: Pijls, B. G., et al.
Publicado: (2018)

Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model
por: Sabaté-Brescó, Marina, et al.
Publicado: (2021)

A TLR2-Activating Fraction From Mycobacterium abscessus Rough Variant Demonstrates Vaccine and Diagnostic Potential
por: Le Moigne, Vincent, et al.
Publicado: (2020)

Orthopaedic device-related infection: current and future interventions for improved prevention and treatment
por: Moriarty, T. Fintan, et al.
Publicado: (2016)

Antifungal prophylaxis with nebulized amphotericin-B in solid-organ transplant recipients with severe COVID-19: a retrospective observational study
por: Rombauts, Alexander, et al.
Publicado: (2023)

Does Implant Coating With Antibacterial-Loaded Hydrogel Reduce Bacterial Colonization and Biofilm Formation in Vitro?
por: Drago, Lorenzo, et al.
Publicado: (2014)

Longitudinal time-lapse in vivo micro-CT reveals differential patterns of peri-implant bone changes after subclinical bacterial infection in a rat model
por: Stadelmann, Vincent A., et al.
Publicado: (2020)

Development and Characterization of a Subcutaneous Implant-Related Infection Model in Mice to Test Novel Antimicrobial Treatment Strategies
por: Wittmann, Charlotte, et al.
Publicado: (2022)

A Novel Strategy to Coat Dopamine-Functionalized Titanium Surfaces With Agarose-Based Hydrogels for the Controlled Release of Gentamicin
por: Soylu, H. Melis, et al.
Publicado: (2021)

Hydrogel-based 3D human iPSC-derived neuronal culture for the study of rabies virus infection
por: Muangsanit, Papon, et al.
Publicado: (2023)

Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies
por: Beddingfield, Brandon J., et al.
Publicado: (2021)

Printability and Shape Fidelity of Bioinks in 3D Bioprinting
por: Schwab, Andrea, et al.
Publicado: (2020)

Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani
por: Zhang, Yumin, et al.
Publicado: (2021)

Efficacy and Safety of Antiviral Agents in Preventing Allograft Rejection Following CMV Prophylaxis in High-Risk Kidney Transplantation: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
por: Ruenroengbun, Narisa, et al.
Publicado: (2022)

Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo
por: Wu, Hong, et al.
Publicado: (2022)

Block and Lock HIV Cure Strategies to Control the Latent Reservoir
por: Ahlenstiel, Chantelle L., et al.
Publicado: (2020)

Thromboembolism prophylaxis in orthopaedics: an update
por: Flevas, Dimitrios A., et al.
Publicado: (2018)

Modulating design parameters to drive cell invasion into hydrogels for osteochondral tissue formation
por: Schwab, Andrea, et al.
Publicado: (2023)

A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses: a proof of principle study
por: Welling, Mick M., et al.
Publicado: (2023)

Editorial: Host-pathogen interactions: the metabolic crossroads
por: Richards, Crystal L., et al.
Publicado: (2023)

Incorporating the Detection of Single Nucleotide Polymorphisms Associated With Invasive Aspergillosis Into the Clinic
por: White, P. Lewis, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bolg831q90t3no8gv4h4m5plkf