Protective autophagy by thymidine causes resistance to rapamycin in colorectal cancer cells in vitro

Aim: Thynidine phosphorylase (TP) acts as a proangiogenic growth factor which may regulate mammalian Target of Rapamycin (mTOR). We investigated whether the TP substrate thymidine and overexpression of TP affected mTOR signaling by comparing Colo320 (TP deficient) cells and its TP-transfected varian...

Descripción completa

Detalles Bibliográficos
Autores principales: Bijnsdorp, I.V., Peters, Godefridus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094079/
https://www.ncbi.nlm.nih.gov/pubmed/35582304
http://dx.doi.org/10.20517/cdr.2021.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094079/
https://www.ncbi.nlm.nih.gov/pubmed/35582304
http://dx.doi.org/10.20517/cdr.2021.21

Ejemplares similares