Induction of neutralizing antibodies against SARS-CoV-2 variants by a multivalent mRNA-lipid nanoparticle vaccine encoding SARS-CoV-2/SARS-CoV Spike protein receptor-binding domains

To address the need for multivalent vaccines against Coronaviridae that can be rapidly developed and manufactured, we compared antibody responses against SARS-CoV, SARS-CoV-2, and several variants of concern in mice immunized with mRNA-lipid nanoparticle vaccines encoding homodimers or heterodimers...

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Detalles Bibliográficos
Autores principales: Zhang, Qiong, Tiwari, Shashi K., Wang, Shaobo, Wang, Lingling, Li, Wanyu, Zhang, Lingzhi, Rawlings, Stephen A., Cheng, Yong, Jokerst, Jesse V., Rana, Tariq M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094100/
https://www.ncbi.nlm.nih.gov/pubmed/35547843
http://dx.doi.org/10.1101/2022.04.28.489834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094100/
https://www.ncbi.nlm.nih.gov/pubmed/35547843
http://dx.doi.org/10.1101/2022.04.28.489834

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