Combining Coarse-Grained Simulations and Single Molecule Analysis Reveals a Three-State Folding Model of the Guanidine-II Riboswitch

Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop interaction between the P1 and P2 hairpins. While...

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Detalles Bibliográficos
Autores principales: Fuks, Christin, Falkner, Sebastian, Schwierz, Nadine, Hengesbach, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094411/
https://www.ncbi.nlm.nih.gov/pubmed/35573739
http://dx.doi.org/10.3389/fmolb.2022.826505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094411/
https://www.ncbi.nlm.nih.gov/pubmed/35573739
http://dx.doi.org/10.3389/fmolb.2022.826505

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