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Combining Coarse-Grained Simulations and Single Molecule Analysis Reveals a Three-State Folding Model of the Guanidine-II Riboswitch

Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop interaction between the P1 and P2 hairpins. While...

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Detalles Bibliográficos
Autores principales:	Fuks, Christin, Falkner, Sebastian, Schwierz, Nadine, Hengesbach, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094411/ https://www.ncbi.nlm.nih.gov/pubmed/35573739 http://dx.doi.org/10.3389/fmolb.2022.826505

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