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Repeated intermittent administration of (R)-ketamine during juvenile and adolescent stages prevents schizophrenia-relevant phenotypes in adult offspring after maternal immune activation: a role of TrkB signaling

Maternal immune activation (MIA) plays a role in the etiology of schizophrenia. MIA by prenatal exposure of polyinosinic:polycytidylic acid [poly(I:C)] in rodents caused behavioral and neurobiological changes relevant to schizophrenia in adult offspring. We investigated whether the novel antidepress...

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Detalles Bibliográficos
Autores principales: Tan, Yunfei, Fujita, Yuko, Pu, Yaoyu, Chang, Lijia, Qu, Youge, Wang, Xinming, Hashimoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095544/
https://www.ncbi.nlm.nih.gov/pubmed/34977960
http://dx.doi.org/10.1007/s00406-021-01365-6