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Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
The kidney is the main organ that senses changes in systemic oxygen tension, but it is also the key detoxification, transit and excretion site of transition metals (TMs). Pivotal to oxygen sensing are prolyl-hydroxylases (PHDs), which hydroxylate specific residues in hypoxia-inducible factors (HIFs)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095554/ https://www.ncbi.nlm.nih.gov/pubmed/35445830 http://dx.doi.org/10.1007/s00204-022-03285-3 |