The bromodomain inhibitor JQ1 up-regulates the long non-coding RNA MALAT1 in cultured human hepatic carcinoma cells

The epigenetic reader, bromodomain-containing 4 (BRD4), is overexpressed in hepatocellular carcinoma (HCC), and BRD4 inhibition is considered as a new therapeutic approach. The BRD inhibitor JQ1 is known to inhibit the enrichment of BRD4 at enhancer sites. Gene network analyses have implicated long...

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Detalles Bibliográficos
Autores principales: Choi, Hae In, An, Ga Yeong, Yoo, Eunyoung, Baek, Mina, Binas, Bert, Chai, Jin Choul, Lee, Young Seek, Jung, Kyoung Hwa, Chai, Young Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095596/
https://www.ncbi.nlm.nih.gov/pubmed/35546353
http://dx.doi.org/10.1038/s41598-022-11868-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095596/
https://www.ncbi.nlm.nih.gov/pubmed/35546353
http://dx.doi.org/10.1038/s41598-022-11868-4

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