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The bromodomain inhibitor JQ1 up-regulates the long non-coding RNA MALAT1 in cultured human hepatic carcinoma cells

The epigenetic reader, bromodomain-containing 4 (BRD4), is overexpressed in hepatocellular carcinoma (HCC), and BRD4 inhibition is considered as a new therapeutic approach. The BRD inhibitor JQ1 is known to inhibit the enrichment of BRD4 at enhancer sites. Gene network analyses have implicated long...

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Detalles Bibliográficos
Autores principales:	Choi, Hae In, An, Ga Yeong, Yoo, Eunyoung, Baek, Mina, Binas, Bert, Chai, Jin Choul, Lee, Young Seek, Jung, Kyoung Hwa, Chai, Young Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095596/ https://www.ncbi.nlm.nih.gov/pubmed/35546353 http://dx.doi.org/10.1038/s41598-022-11868-4

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