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Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP

Energy restriction (ER) protects against cerebral ischemic injury, but the underlying mechanism remains largely unclear. Here, rats were fed ad libitum (AL) or on an alternate-day food deprivation intermittent fasting (IF) diet for 3 months, followed by middle cerebral artery occlusion (MCAO) surger...

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Detalles Bibliográficos
Autores principales: Song, Ming-Yu, Yi, Fang, Xiao, Hui, Yin, Jun, Huang, Qing, Xia, Jian, Yin, Xiao-Meng, Wen, Yan-Bin, Zhang, Le, Liu, Yun-Hai, Xiao, Bo, Gu, Wen-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095711/
https://www.ncbi.nlm.nih.gov/pubmed/35562171
http://dx.doi.org/10.1038/s41419-022-04866-x