Cargando…

Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor

An absolute or relative deficiency of pancreatic β-cells mass and functionality is a crucial pathological feature common to type 1 diabetes mellitus and type 2 diabetes mellitus. Glucagon-like-peptide-1 receptor (GLP1R) agonists have been the focus of considerable research attention for their abilit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Girdhar, Khyati, Thakur, Shilpa, Gaur, Pankaj, Choubey, Abhinav, Dogra, Surbhi, Dehury, Budheswar, Kumar, Sunil, Biswas, Bidisha, Dwivedi, Durgesh Kumar, Ghosh, Subrata, Mondal, Prosenjit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095748/ https://www.ncbi.nlm.nih.gov/pubmed/35378127 http://dx.doi.org/10.1016/j.jbc.2022.101889

Ejemplares similares

Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation
por: Rawat, Priya, et al.
Publicado: (2023)

LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone
por: Shitole, Pankaj, et al.
Publicado: (2021)

NF-κB p65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet
por: Daniel, P. Vineeth, et al.
Publicado: (2021)

Novel insights into structure–function mechanism and tissue-specific expression profiling of full-length dxr gene from Cymbopogon winterianus
por: Devi, Kamalakshi, et al.
Publicado: (2015)

Identification of phytocompounds as newer antiviral drugs against COVID-19 through molecular docking and simulation based study
por: Kar, Bipasa, et al.
Publicado: (2022)

Exploiting the potential of natural polyphenols as antivirals against monkeypox envelope protein F13 using machine learning and all-atoms MD simulations
por: Rout, Madhusmita, et al.
Publicado: (2023)

Phenethylisothiocyanate Potentiates Platinum Therapy by Reversing Cisplatin Resistance in Cervical Cancer
por: Mahapatra, Elizabeth, et al.
Publicado: (2022)

Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1
por: Dehury, Budheswar, et al.
Publicado: (2019)

Role of Voluminous Substituents in Controlling the Optical Properties of Disc/Planar-Like Small Organic Molecules: Toward Molecular Emission in Solid State
por: Kumar, Sunil, et al.
Publicado: (2017)

The molecular pharmacology of glucagon agonists in diabetes and obesity
por: Novikoff, Aaron, et al.
Publicado: (2023)

Structural insights into the RNA interaction with Yam bean Mosaic virus (coat protein) from Pachyrhizus erosus using bioinformatics approach
por: Acharya, Varsha, et al.
Publicado: (2022)

Altered Levels of Serum Zinc and Cadmium in Patients with Chronic Vesiculobullous Hand and Feet Dermatitis
por: Suvirya, Swastika, et al.
Publicado: (2016)

Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature
por: Dehury, Budheswar, et al.
Publicado: (2020)

Drug repurposing for Mpox: Discovery of small molecules as potential inhibitors against DNA‐dependent RNA polymerase using molecular modeling approach
por: Dutt, Mansi, et al.
Publicado: (2023)

Insights into structure and dynamics of extracellular domain of Toll-like receptor 5 in Cirrhinus mrigala (mrigala): A molecular dynamics simulation approach
por: Rout, Ajaya Kumar, et al.
Publicado: (2021)

DBCOVP: A database of coronavirus virulent glycoproteins
por: Sahoo, Susrita, et al.
Publicado: (2021)

A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro
por: Verma, Mahesh Kumar, et al.
Publicado: (2014)

ESMP: A high-throughput computational pipeline for mining SSR markers from ESTs
por: Sarmah, Ranjan, et al.
Publicado: (2012)

An approach to delineate primers for a group of poorly conserved sequences incorporating the common motif region
por: Sahu, Mousumi, et al.
Publicado: (2012)

Mining for SSRs and FDMs from expressed sequence tags of Camellia sinensis
por: Sahu, Jagajjit, et al.
Publicado: (2012)

Structure-Based Computational Study of Two Disease Resistance Gene Homologues (Hm1 and Hm2) in Maize (Zea mays L.) with Implications in Plant-Pathogen Interactions
por: Dehury, Budheswar, et al.
Publicado: (2014)

Delineation of molecular interactions of plant growth promoting bacteria induced β-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach
por: Jha, Yachana, et al.
Publicado: (2021)

Cardiovascular Effects of Glucagon-Like Peptide-1 Receptor Agonists
por: Kang, Yu Mi, et al.
Publicado: (2016)

How glucagon-like peptide 1 receptor agonists work
por: Andreasen, Christine Rode, et al.
Publicado: (2021)

Glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes
por: Lee, Seungah, et al.
Publicado: (2017)

Conformation Transition of Intracellular Part of Glucagon Receptor in Complex With Agonist Glucagon by Conventional and Accelerated Molecular Dynamics Simulations
por: Bai, Qifeng, et al.
Publicado: (2019)

Community Profiling of Culturable Fluorescent Pseudomonads in the Rhizosphere of Green Gram (Vigna radiata L.)
por: Sarma, Rupak K., et al.
Publicado: (2014)

Molecular cloning, GTP recognition mechanism and tissue-specific expression profiling of myxovirus resistance (Mx) protein in Labeo rohita (Hamilton) after Poly I:C induction
por: Das, Basanta Kumar, et al.
Publicado: (2019)

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes
por: Mahapatra, Manoj Kumar, et al.
Publicado: (2022)

Dendritic Polynitrato Energetic Motifs: Development and Exploration of Physicochemical Behavior through Theoretical and Experimental Approach
por: Gaur, Pankaj, et al.
Publicado: (2017)

Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae
por: Swain, Shasank S., et al.
Publicado: (2020)

Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors
por: Jones, Ben, et al.
Publicado: (2020)

Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists
por: Zhang, Yu-Juan, et al.
Publicado: (2013)

Glucagon‐like peptide‐1 receptor agonists and their effects on weight reduction
por: Shin, Shyi‐Jang
Publicado: (2012)

Glucagon-Like Peptide 1 Receptor Agonists for Type 2 Diabetes
por: Hinnen, Deborah
Publicado: (2017)

The potential of glucagon-like peptide-1 receptor agonists in heart failure
por: Kreiner, Frederik Flindt, et al.
Publicado: (2022)

Glucagon-like peptide-1 receptor agonists in patients treated with antipsychotics
por: Delgado, A., et al.
Publicado: (2021)

Glucagon-Like Peptide-1 Receptor Agonists for Chronic Weight Management
por: Wojtara, Magda, et al.
Publicado: (2023)

Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes
por: Eriksson, Olof, et al.
Publicado: (2020)

Kanamycin-Mediated Conformational Dynamics of Escherichia coli Outer Membrane Protein TolC
por: Pattanayak, Biraja S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ss8hqtbcorubm2ajrt5g3fc2ed