FAK PROTAC Inhibits Ovarian Tumor Growth and Metastasis by Disrupting Kinase Dependent and Independent Pathways

Focal adhesion kinase (FAK) is highly expressed in a variety of human cancers and is a target for cancer therapy. Since FAK kinase inhibitors only block the kinase activity of FAK, they are not highly effective in clinical trials. FAK also functions as a scaffold protein in a kinase-independent path...

Descripción completa

Detalles Bibliográficos
Autores principales: Huo, Xueyun, Zhang, Wenjing, Zhao, Guannan, Chen, Zhenwen, Dong, Peixin, Watari, Hidemichi, Narayanan, Ramesh, Tillmanns, Todd D., Pfeffer, Lawrence M., Yue, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095959/
https://www.ncbi.nlm.nih.gov/pubmed/35574330
http://dx.doi.org/10.3389/fonc.2022.851065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095959/
https://www.ncbi.nlm.nih.gov/pubmed/35574330
http://dx.doi.org/10.3389/fonc.2022.851065

Ejemplares similares