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Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
As there are no clear on-target mechanisms that explain the increased risk for thrombosis and viral infection or reactivation associated with JAK inhibitors, the observed elevated risk may be a result of an off-target effect. Computational approaches combined with in vitro studies can be used to pre...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096754/ https://www.ncbi.nlm.nih.gov/pubmed/35551258 http://dx.doi.org/10.1038/s41598-022-11879-1 |