Palbociclib-based high-throughput combination drug screening identifies synergistic therapeutic options in HPV-negative head and neck squamous cell carcinoma

BACKGROUND: Deregulation of cell-cycle pathway is ubiquitously observed in human papillomavirus negative (HPV(neg)) head and neck squamous cell carcinoma (HNSCC). Despite being an attractive target, CDK4/6 inhibition using palbociclib showed modest or conflicting results as monotherapy or in combina...

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Detalles Bibliográficos
Autores principales: Gu, Ziyue, Shi, Chaoji, Li, Jiayi, Han, Yong, Sun, Bao, Zhang, Wuchang, Wu, Jing, Zhou, Guoyu, Ye, Weimin, Li, Jiang, Zhang, Zhiyuan, Zhou, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097351/
https://www.ncbi.nlm.nih.gov/pubmed/35546399
http://dx.doi.org/10.1186/s12916-022-02373-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097351/
https://www.ncbi.nlm.nih.gov/pubmed/35546399
http://dx.doi.org/10.1186/s12916-022-02373-6

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