Cargando…

PRDM1 Drives Human Primary T Cell Hyporesponsiveness by Altering the T Cell Transcriptome and Epigenome

T cell hyporesponsiveness is crucial for the functional immune system and prevents the damage induced by alloreactive T cells in autoimmune pathology and transplantation. Here, we found low expression of PRDM1 in T cells from donor and recipients both related to the occurrence of acute graft-versus-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Huidong, Wang, Ming, Wang, Bixia, Guo, Liping, Cheng, Yifei, Wang, Zhidong, Sun, Yu-Qian, Wang, Yu, Chang, Ying-Jun, Huang, Xiao-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097451/ https://www.ncbi.nlm.nih.gov/pubmed/35572579 http://dx.doi.org/10.3389/fimmu.2022.879501

Ejemplares similares

Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity
por: Maggi, Jaxaira, et al.
Publicado: (2015)

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids
por: Correia-Neves, Margarida, et al.
Publicado: (2022)

Vitamin D3-Induced Tolerogenic Dendritic Cells Modulate the Transcriptomic Profile of T CD4(+) Cells Towards a Functional Hyporesponsiveness
por: Navarro-Barriuso, Juan, et al.
Publicado: (2021)

Redox Balance Alterations and Hyporesponsiveness of Synovial T Cells in Rheumatoid Arthritis
por: Breedveld, Ferdinand C, et al.
Publicado: (2000)

Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness
por: Segerberg, Filip, et al.
Publicado: (2019)

Epigenomic Views of Innate Lymphoid Cells
por: Sciumè, Giuseppe, et al.
Publicado: (2017)

Decoding lymphomyeloid divergence and immune hyporesponsiveness in G-CSF-primed human bone marrow by single-cell RNA-seq
por: You, Guoju, et al.
Publicado: (2022)

Contribution of IL-17 in Steroid Hyporesponsiveness in Obese Asthmatics Through Dysregulation of Glucocorticoid Receptors α and β
por: Al Heialy, Saba, et al.
Publicado: (2020)

Ionomycin Treatment Renders NK Cells Hyporesponsive
por: Romera-Cárdenas, Gema, et al.
Publicado: (2016)

NK Cell Hyporesponsiveness: More Is Not Always Better
por: Frutoso, Marie, et al.
Publicado: (2019)

Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish
por: Perdiguero, Pedro, et al.
Publicado: (2020)

NonO Is a Novel Co-factor of PRDM1 and Regulates Inflammatory Response in Monocyte Derived-Dendritic Cells
por: Lee, Kyungwoo, et al.
Publicado: (2020)

Adoptive Cell Therapy Targeting Neoantigens: A Frontier for Cancer Research
por: Wang, Zhidong, et al.
Publicado: (2020)

Altering cancer transcriptomes using epigenomic inhibitors
por: Gaddis, Malaina, et al.
Publicado: (2015)

Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy
por: Kropf, Pascale, et al.
Publicado: (2007)

Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development
por: Zhong, Suijuan, et al.
Publicado: (2023)

Low expression of PRDM5 predicts poor prognosis of esophageal squamous cell carcinoma
por: Guo, Jing, et al.
Publicado: (2022)

MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma
por: Li, Meng, et al.
Publicado: (2022)

miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells
por: Lei, Qianqian, et al.
Publicado: (2015)

Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins
por: Lu, Mingmin, et al.
Publicado: (2020)

Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma
por: Zhang, Yunlong, et al.
Publicado: (2023)

The methylation profiles of PRDM promoters in non–small cell lung cancer
por: Tan, Shuang-xiang, et al.
Publicado: (2018)

Desensitization induces hyporesponsiveness and cell-surface phenotype changes on mouse mast cells
por: Giavina-Bianchi, Pedro, et al.
Publicado: (2014)

Congenital insensitivity to pain associated with PRDM12 mutation: Two case reports and a literature review
por: Yu, Hanrui, et al.
Publicado: (2023)

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics
por: Li, Ruonan, et al.
Publicado: (2023)

Functional Characterization of Human T Cell Hyporesponsiveness Induced by CTLA4-Ig
por: Rochman, Yrina, et al.
Publicado: (2015)

Labial Gland Mesenchymal Stem Cell Derived Exosomes-Mediated miRNA-125b Attenuates Experimental Sjogren’s Syndrome by Targeting PRDM1 and Suppressing Plasma Cells
por: Xing, Yixiao, et al.
Publicado: (2022)

BTECH: A Platform to Integrate Genomic, Transcriptomic and Epigenomic Alterations in Brain Tumors
por: Wang, Min, et al.
Publicado: (2011)

Integrative analysis of spatial transcriptome with single-cell transcriptome and single-cell epigenome in mouse lungs after immunization
por: Xu, Zhongli, et al.
Publicado: (2022)

Increased Cathepsin S in Prdm1−/− dendritic cells alters T(FH) repertoire and contributes to lupus
por: Kim, Sun Jung, et al.
Publicado: (2017)

Epigenomics and Early Life Human Humoral Immunity: Novel Paradigms and Research Opportunities
por: Gutierrez, Maria J., et al.
Publicado: (2020)

An Exploratory Study of Daprodustat in Erythropoietin-Hyporesponsive Subjects
por: Cizman, Borut, et al.
Publicado: (2018)

Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)
por: Leszczyński, Paweł, et al.
Publicado: (2020)

Low-Dose 5-Aza and DZnep Alleviate Acute Graft-Versus-Host Disease With Less Side Effects Through Altering T-Cell Differentiation
por: Wang, Qing Ya, et al.
Publicado: (2022)

Epigenomic Modifications Mediating Antibody Maturation
por: Sheppard, Emily C., et al.
Publicado: (2018)

Single-cell transcriptome and epigenomic reprogramming of cardiomyocyte-derived cardiac progenitor cells
por: Chen, Xin, et al.
Publicado: (2016)

Alzheimer’s disease alters the transcriptomic profile of natural killer cells at single-cell resolution
por: Qi, Caiyun, et al.
Publicado: (2022)

Single-Cell Transcriptomics of Immune Cells Reveal Diversity and Exhaustion Signatures in Non-Small-Cell Lung Cancer
por: Zhao, Ying, et al.
Publicado: (2022)

Functions of Prdm16 in thermogenic fat cells
por: Ishibashi, Jeff, et al.
Publicado: (2015)

PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm
por: Wang, Zhenguo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0mrg1n947h0igpddn9vduqqb98