Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module

The major heat shock protein Hsp70 forms a complex with a scaffold protein Bag3 that links it to components of signaling pathways. Via these interactions, the Hsp70-Bag3 module functions as a proteotoxicity sensor that controls cell signaling. Here, to search for pathways regulated by the complex, w...

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Detalles Bibliográficos
Autores principales: Patel, Shivani, Kumar, Santosh, Baldan, Simone, Hesin, Arkadi, Yaglom, Julia, Sherman, Michael Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097715/
https://www.ncbi.nlm.nih.gov/pubmed/35573186
http://dx.doi.org/10.1016/j.isci.2022.104282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097715/
https://www.ncbi.nlm.nih.gov/pubmed/35573186
http://dx.doi.org/10.1016/j.isci.2022.104282

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