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Can 3D diploid genome reconstruction from unphased Hi-C data be salvaged?
The three-dimensional (3D) configuration of chromatin impacts numerous cellular processes. However, directly observing chromatin architecture at high resolution is challenging. Accordingly, inferring 3D structure utilizing chromatin conformation capture assays, notably Hi-C, has received considerabl...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097817/ https://www.ncbi.nlm.nih.gov/pubmed/35571676 http://dx.doi.org/10.1093/nargab/lqac038 |