Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis

Emerging studies indicate that intracellular eukaryotic ceramide species directly activate cathepsin B (CatB), a lysosomal‐cysteine‐protease, in the cytoplasm of osteoclast precursors (OCPs) leading to elevated RANKL‐mediated osteoclastogenesis and inflammatory osteolysis. However, the possible impa...

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Detalles Bibliográficos
Autores principales: Duarte, Carolina, Yamada, Chiaki, Garcia, Christopher, Akkaoui, Juliet, Ho, Anny, Nichols, Frank, Movila, Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097840/
https://www.ncbi.nlm.nih.gov/pubmed/35429112
http://dx.doi.org/10.1111/jcmm.17299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097840/
https://www.ncbi.nlm.nih.gov/pubmed/35429112
http://dx.doi.org/10.1111/jcmm.17299

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