Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma

INTRODUCTION: Nephrilin peptide, a designed inhibitor of Rictor complex, modulates systemic responses to trauma, alleviating clinically relevant variables in a rat scald model and sepsis mortality in a mouse model. This study explores the possibility that chemical conjugation of small molecules to t...

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Detalles Bibliográficos
Autores principales: Mascarenhas, Desmond D., Ravikumar, Puja, Amento, Edward P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097890/
https://www.ncbi.nlm.nih.gov/pubmed/35572093
http://dx.doi.org/10.1016/j.burnso.2020.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097890/
https://www.ncbi.nlm.nih.gov/pubmed/35572093
http://dx.doi.org/10.1016/j.burnso.2020.06.002

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