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Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma
INTRODUCTION: Nephrilin peptide, a designed inhibitor of Rictor complex, modulates systemic responses to trauma, alleviating clinically relevant variables in a rat scald model and sepsis mortality in a mouse model. This study explores the possibility that chemical conjugation of small molecules to t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097890/ https://www.ncbi.nlm.nih.gov/pubmed/35572093 http://dx.doi.org/10.1016/j.burnso.2020.06.002 |