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Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake

Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc(DA)) inhibit target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) receptors. However, the molecular mechanisms responsible for GABAergic signaling remain unclear, as SNc(DA) neurons lack...

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Detalles Bibliográficos
Autores principales: Melani, Riccardo, Tritsch, Nicolas X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097974/
https://www.ncbi.nlm.nih.gov/pubmed/35443174
http://dx.doi.org/10.1016/j.celrep.2022.110716