Cargando…
Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake
Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc(DA)) inhibit target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) receptors. However, the molecular mechanisms responsible for GABAergic signaling remain unclear, as SNc(DA) neurons lack...
Autores principales: | Melani, Riccardo, Tritsch, Nicolas X. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097974/ https://www.ncbi.nlm.nih.gov/pubmed/35443174 http://dx.doi.org/10.1016/j.celrep.2022.110716 |
Ejemplares similares
-
Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis
por: Tritsch, Nicolas X, et al.
Publicado: (2014) -
Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro
por: Geldwert, Daron, et al.
Publicado: (2006) -
Reliability in the Identification of Midbrain Dopamine Neurons
por: Margolis, Elyssa B., et al.
Publicado: (2010) -
Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
por: Tritsch, Nicolas X., et al.
Publicado: (2012) -
Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum
por: Maltese, Marta, et al.
Publicado: (2021)